Methylcobalamin

An enhanced form of vitamin B12 called methylcobalamin offers advantages over all other forms of B12, including injections given by your doctor. Methylcobalamin is a highly bioavailable form of B12 that does not require intrinsic factor. The sublingual form of methylcobalamin B12 offers even further advantages as it dissolves quickly under the tongue and is readily absorbed directly into the blood stream, bypassing digestion. Blood levels of B12 indicate that sublingual B12 becomes available as early as 15 minutes after administration and is still elevated 24 hours later. When used daily, this form maintains a sufficient B12 level, in contrast to injections, which provide a B12 surge followed by a progressive drop until the next injection. An editorial entitled "Oral Cobalamin for Pernicious Anemia: Medicine's Best-Kept Secret," which appeared in JAMA, confirmed that oral therapy is a reliable and effective treatment even in severe cases of pernicious anemia. So although it is popular to inject B12, it is not necessary. Furthermore, the costs of administering B12 injections can be prohibitive for many patients, whereas oral B12 can be self administered and is therefore more affordable.

The Science behind the Vitamin B12 sublingual

Here is why you might not be getting your B12 with those other vitamins! When the B12 vitamin enters your body in the stomach (through food or oral pills), acids in the stomach separate the B12 from its protein source. It then must combine with intrinsic factor cells in the stomach. This B12/intrinsic factor complex travels to your intestine, where it is absorbed in the terminal ileum. The absorbed complex is then transported via blood plasma and stored in the liver. The interruption of any of these steps affects your body's ability to absorb B12.

Common B12 absorption problems

As you age (over 45) or become overly reliant on acid suppressing agents like antacids, your ability to produce gastric acids in the stomach decreases, meaning that the B12 is less likely to be released from its food source. An autoimmune or other disease reduces the production or blocks the action of intrinsic factor, resulting in intestinal malabsorption. People with pernicious anemia have decreased production of intrinsic factor. Abdominal surgery reduces B12 absorption. Gastrectomy eliminates the site of intrinsic factor production. Blind loop syndrome results in competition for vitamin B12 by bacterial overgrowth in the lumen of the small intestine. Surgical resection of the ileum eliminates the site of vitamin B12 absorption. Pancreatic insufficiency such as fish tapeworm infection and severe Crohn's disease affect absorption.
With Nurovita sublingual tablets you can now have confidence knowing that your body is getting the B12 it needs!
Nurovita provides the most active form of B12 and is available as well. It is quickly absorbed in the bloodstream through sublingual tissues.

How B12 works

Vitamin B12, like folic acid, functions as a "methyl donor". A methyl donor is simply any substance that can transfer a methyl group (a carbon atom attached to three hydrogen atoms) to another substance. Referred to as methylation, many important biochemical functions rely on this process, such as proper energy metabolism, immune function, and nerve function. More specifically, methyl donors help in the production of several brain chemicals and hence improve cognitive function, mood, energy, and sleep. As we age our body's ability to methylate declines, contributing to the aging process.

Vitamin B12 Deficiency


( I ) Causes

a). Medications Affecting Cobalamin.

  1. Megaloblastic Macrocytic Anemia

    (I) Folate Related Changes
       1. Oral Contraceptive Use
       2. Pyrimethamine (Daraprim)
       3. Triamterene
       4. Alcohol
       5. Biguanides
           1. Methotrexate
           2. Cholestyramine (Questran)
       6. Anticonvulsants
           1. Phenytoin (Dilantin)
           2. Primidone (Mysoline)
           3. Phenobarbital
           4. Valproic Acid (Depakote)
       7. Antibiotics
           1. Sulfasalazine (Azulfidine)
           2. Sulfamethoxazole
           3. Trimethoprim (e.g. Bactrim or Septra)
           4. Pentamidine
       8. Reverse transcriptase inhibitors (HIV Medications)
           1. Stavudine (Zerit)
           2. Lamivudine (Epivir)
           3. Zidovudine (Retrovir)

    (II) Vitamin B12 Related Changes
       1. Gastric acid-blocking agents
           1. Proton Pump Inhibitors (e.g. Omeprazole)
           2. Histamine H2-receptor blockers (e.g. Ranitidine)
       2. Colchicine        
       3. Neomycin sulfate
       4. Nitrous oxide
       5. Para-aminosalicylic Acid

  2. Non-megaloblastic Macrocytic Anemia (Marrow Toxins)
       1. Methotrexate
       2. Daunorubicin
       3. Adriamycin
       4. Benzene and derivatives (e.g. trinitrotoluene)
       5. Purine antagonists
           1. 6-Mercaptopurine
           2. Thioguanine
           3. Azathioprine (Imuran)
           4. Acyclovir (Zovirax)
       6. Pyrimidine antagonists
           1. Fluorouracil (Adrucil)
           2. Floxuridine (FUDR)
           3. Azidouridine
           4. Zidovudine (Retrovir)
       7. Ribonucleotide Reduction Inhibitors
           1. Hydroxyurea
           2. Cytosine arabinoside
       8. Alkylating Agents
           1. Cyclophosphamide (Cytoxan)
           2. Busulfan

b). Pernicious Anemia
  1. Autoimmune parietal cell destruction
  2. Results in insufficient intrinsic factor production

c). Elderly with atrophic Gastritis (10-30% over age 60)
  1. Can not absorb Vitamin B12 bound to protein
  2. However can absorb crystalline Vitamin B12 normally

d). Malabsorption
  1. Crohn's Disease
  2. Zollinger-Ellison Syndrome (Gastrinoma)
  3. Whipple's Disease
  4. Intestinal infection (e.g. parasite or Tapeworm)
  5. Blind Loop Syndrome (Gastrectomy and ileal resection)

e). Inadequate Vitamin B12 intake
  1. Vegan
  2. Elderly
  3. Alcoholism

f). Miscellaneous Causes (uncommon)
  1. Nitrous oxide abuse
  2. Diphyllobothrium latum (fish Tapeworm) infection
  3. Inherited disorders of Cobalamin metabolism (Imerslund Syndrome)

( II ) Signs

a). Early Signs B12 Deficiency
  1. Unusual fatigue
  2. Faulty digestion
  3. No appetite
  4. Nausea
  5. Loss of menstruation

b). Signs of a More Severe B12 Deficiency
  1. Numbness and tingling of the hands and feet
  2. Nervousness
  3. Diarrhea
  4. Mild depression
  5. Paranoia
  6. Hyperactive reflexes
  7. Fever
  8. Frequent upper respiratory infections
  9. Impotence
  10. Impaired memory
  11. Infertility
  12. Sore tongue
  13. Macrocytic anemia
  14. Low platelet count and increased bleeding
  15. Neutropenia



Health Benefits of Vitamin B12

A). Cardiovascular System
1- May help to prevent Atherosclerosis (primarily through its effect on reducing toxic levels of Homocysteine that are implicated in Atherosclerosis).
2-May help to prevent Heart Attacks (by lowering elevated Homocysteine levels).
3- May help to protect against the after-effects of (ischemic) Stroke. In addition, Vitamin B12 may help to prevent Strokes (by helping to lower elevated Homocysteine levels).

B). Red blood cells
1- Vitamin B12 is required for the formation of Red Blood Cells.
2- Alleviates Macrocytic and Megaloblastic Anemia.
3- Oral Vitamin B12 therapy produces reliable and effective treatment in severe cases of Pernicious Anemia

C). Cells
1-Vitamin B12 may be essential for the production of all Epithelial Cells.
2- Vitamin B12 is necessary for the production of nucleic acids, which make up DNA.

D). Digestive System
1-Vitamin B12 may enhance the general health of the Digestive System.
2- Vitamin B12 alleviates Crohn's Disease but does imply that Crohn's Disease patients may need to supplement with Vitamin B12 in order to avoid Vitamin B12 deficiency - the sole absorption site for Vitamin B12 is in the Ileum (the same site that is most commonly impaired by Crohn's Disease).

E). Ears/Hearing
1-Vitamin B12 may improve hearing due to its ability to enhance the conduction of nerve impulses relating to hearing in some cases of (chronic) Noise-Induced Hearing Loss (27% of people afflicted with chronic Noise-Induced Hearing Loss exhibit Vitamin B12 deficiency).
2- Important in some cases of Tinnitus may be attributable to Vitamin B12 deficiency (47% of Tinnitus patients exhibit Vitamin B12 deficiency).

F). Eyes/Vision
1-Vitamin B12 may help to prevent Cataracts.
2-Vitamin B12 (Methylcobalamin form) may help to prevent Glaucoma (by inhibiting the toxicity of Glutamic Acid, a suspected cause of Glaucoma; and by preserving Myelin).
3- Improve optic nerve, because vitamin B12 deficiency may impair the function of the Optic Nerve.

G). Immune System
1-Vitamin B12 may accelerate the recovery from Bacterial & Viral Diseases.
2-Vitamin B12 may optimize the ratios of the various types of White Blood Cells and may raises suppressed White Blood Cell counts.
3-Vitamin B12 May Decrease the susceptibility to Helicobacter pylori infection.
4-Vitamin B12 (1 - 2 mg per day) improves the condition of Viral Hepatitis patients. Vitamin B12 may be useful for the treatment of Hepatitis C.
5-Vitamin B12 may help to prevent Breast Cancer.
6-Vitamin B12 may help to prevent Cervical Cancer.
7-Fever (of unknown origin) is one of the symptoms of Vitamin B12 deficiency.
8-Giardiasis may impair the absorption of Vitamin B12. Vitamin B12 supplementation may help to overcome this impaired absorption.
9-Vitamin B12 may help to prevent Lung Cancer. One clinical study demonstrated that 10 mg Folic Acid combined with 500 micrograms Vitamin B12 per day reduced the incidence of precancerous changes in the Lungs of heavy Tobacco smokers.
10-Vitamin B12 (1 mg per day) may alleviate Systemic Lupus Erythematosus (SLE). In one study, 100% of SLE patients receiving 1mg of Vitamin B12 per day for six weeks experienced complete clearance of SLE lesions.
11- May stimulate the production of Helper T-Cells.
12-Vitamin B12 may stimulate the body's production of Lymphocytes.

H). Metabolism
1-Vitamin B12 is essential for metabolism of fats and carbohydrates and the synthesis of proteins.
2- Vitamin B12 is essential for the transport and storage of folate in cells and for conversion to its active form. Rapidly dividing cells, such as those in the epithelium and bone marrow, have the greatest need for vitamin B12.

I). Bone health
1- Increase bone denser and help to avoid a fracture.
2- Vitamin B12 reduces osteoporosis.

J). Oral Health
1-Vitamin B12 may alleviate Burning Mouth Syndrome, Dry Mouth and Mouth Ulcers.
2- May help to prevent Angular Stomatosis (cracks in the corners of the Mouth).
3- Vitamin B12 may alleviate Glossitis (red, sore, smooth Tongue).

K). Respiratory System
Extra vitamin B-12 may reduce asthma symptoms even if you don't have a deficiency.

L). Sexual System
1- Vitamin B12 may help in Female Infertility.
2- Vitamin B12 (1 - 6 mg per day) may increase Sperm counts in men afflicted with Male Infertility. 3-May help in Male Impotence.

M). Skin/Nails
1-Vitamin B12 (1 mg per day) may alleviate (chronic) Dermatitis.
2-Vitamin B12 (1 mg per day) may alleviate some (approximately 60% of) cases of (atopic) Eczema. 3-Vitamin B12 (1 mg per day) may alleviate many (approximately 90% of cases of) Hives.
4-Vitamin B12 therapy may alleviate some cases of Psoriasis.
5-Vitamin B12 may help to alleviate the pain associated with the (post herpetic) Neuralgia associated with Shingles.

N). Nervous System
1-Vitamin B12 (3 mg per day of the Methylcobalamin form) may increase Alertness.
2-Vitamin B12 (25 mg per day of the Methylcobalamin form) may improve Muscle function in Amyotrophic Lateral Sclerosis (ALS) patients.
3-Vitamin B12 (administered concurrently with Folic Acid) may alleviate Anxiety.
4-Vitamin B12 (Methylcobalamin form) may accelerate recovery from Bells Palsy.
5-Vitamin B12 may help to normalize Circadian Rhythm (probably by facilitating the endogenous production of Melatonin).
6-Vitamin B12 (3 mg per day of the Methylcobalamin form) may improve Concentration ability.
7-Vitamin B12 may alleviate Delayed Sleep Phase Disorder.
8-Vitamin B12 may improve some aspects (Frontal Lobe function and language skills) of Dementia. 9-Supplemental Vitamin B12 may improve various aspects of Intelligence in Alzheimer's Disease patients.
10-Vitamin B12 supplementation alleviates many cases of Major Depression (especially in elderly people).
11-Vitamin B12 may help to rectify some of the underlying biochemical disturbances associated with Down's Syndrome.
12-Vitamin B12 may alleviate Insomnia (by increasing endogenous Melatonin levels early in the night and reducing Melatonin levels at then end of a nights Sleep).
13-Vitamin B12 may improve some aspects of Intelligence.
14-Vitamin B12 may improve the rate of Learning.
15-Vitamin B12 may help to prevent Migraines and may reduce the severity and duration of Migraines.
16-Vitamin B12 (Methylcobalamin form) may improve some aspects of Multiple Sclerosis.
17-Supplementation with massive doses of Vitamin B12 (oral administration of 60 mg of the Methylcobalamin form) may improve visual and brainstem auditory-evoked nerve potentials by up to 30% in Multiple Sclerosis (MS) patients, but does NOT improve motor function. Note that forms of Vitamin B12 other than Methylcobalamin are unsuccessful for the treatment of MS.
18-Vitamin B12 may facilitate the production of Ribonucleic Acid (RNA) within Neurons and the Methylcobalamin form of Vitamin B12 helps to prevent the damage to Neurons caused by exposure to excessive levels of Glutamic Acid.
19-Vitamin B12 (especially the Methylcobalamin form) may facilitate the regeneration of damaged Axons.
20-The (active coenzyme) Adenosylcobalamin or Methylcobalamin forms of Vitamin B12 help to maintain the correct Fatty Acids environment in the Myelin Sheaths that surround Neurons.
21-Vitamin B12 (especially the Methylcobalamin form) may facilitate the regeneration of degenerated Presynaptic Terminals.
22-Vitamin B12 may facilitate the incorporation of the correct Amino Acids (especially Leucine) into Schwann Cells.
23-Vitamin B12 may help to alleviate the Pain associated with the (post herpetic) Neuralgia associated with Shingles.
24-Vitamin B12 may alleviate Neuropathy.
25-Vitamin B12 (administered concurrently with Folic Acid) may help to control Panic Disorder.
26-Vitamin B12 (administered via intramuscular injection) may reduce the Pain associated with Sciatica. It is speculated that oral Vitamin B12 may also be effective.
27-Vitamin B12 may improve the quality of Sleep (by increasing endogenous Melatonin levels early in the night and reducing Melatonin levels at the end of a night's Sleep).

Comparing other forms of B12

Cyanocobalamin is the most common, but not the best, form of vitamin B12. While cyanocobalamin may help healthy young people avoid some forms of anemia, it doesn't convert to enough methylcobalamin to correct other forms of anemia, neurological defects, or age-related cognitive decline, as larger doses are needed to regenerate neurons and the myelin sheath that protects axions and peripheral nerves. There are two reasons why oral cyanocobalamin is inferior. First, enough of the protein intrinsic factor, normally found in stomach acid, must be produced for absorption. Surprising numbers of people, both young and old, have a problem producing enough intrinsic factor. Second, even if cyanocobalamin is absorbed, the liver converts only about 1% of it to its active form, methylcobalamin. Methylcobalamin is already in the active form, and as the tablet dissolves under the tongue, the B12 immediately starts to benefit the blood, brain, and body. Two other forms of B12, hydroxocobalamin and adenosylcobalamin, while better than cyanocobalamin, are no match for superior sublingual methylcobalamin. Sublingual methylcobalamin has also produced better results in clinical trials than cyanocobalamin and other forms of B12.




NUROVITA

• Effectively supports brain, improves memory and nerve function.
• Improves cognitive function, especially in the elderly.
• Is a supportive treatment for persons with severe neurological disorders.
• Helps in the treatment of sleep/wake disorders. • Improves daytime alertness in shift workers and the elderly.
• Lowers homocysteine levels, reducing cardiovascular disease risk.
• Ideal for vegetarians, who have a greater risk of a B12 deficiency.
• Gives you a boost of energy and alertness.


Dosage

Take 1-2 tablets daily away from food, or as directed by a health care professional. Hold tablet under tongue for 1minute or until it is completely dissolved.


Safety and Toxicity

Methylcobalamin has excellent tolerability and no known toxicity.







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